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dc.contributor.authorKovanen, Vuokko
dc.contributor.authorAukee, Pauliina
dc.contributor.authorKokko, Katja
dc.contributor.authorFinni Juutinen, Taija
dc.contributor.authorTarkka, Ina
dc.contributor.authorTammelin, Tuija
dc.contributor.authorKujala, Urho
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorLaakkonen, Eija
dc.date.accessioned2018-08-22T10:16:10Z
dc.date.available2018-08-22T10:16:10Z
dc.date.issued2018
dc.identifier.citationKovanen, V., Aukee, P., Kokko, K., Finni Juutinen, T., Tarkka, I., Tammelin, T., Kujala, U., Sipilä, S., & Laakkonen, E. (2018). Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-related differences in blood count. <i>Menopause: The Journal of The North American Menopause Society</i>, <i>25</i>(9), 1020-1032. <a href="https://doi.org/10.1097/GME.0000000000001117" target="_blank">https://doi.org/10.1097/GME.0000000000001117</a>
dc.identifier.otherCONVID_28047606
dc.identifier.otherTUTKAID_77610
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59306
dc.description.abstractObjective: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones. Methods: Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were constructed to estimate the association of 17b-estradiol (E2) and FSH with the blood count variables. Results: In all, 3,064 women returned the prequestionnaire (ERMA phase one), 1,393 donated blood samples and were assigned to the relevant menopausal group (phase two), and 914 completed phase three, which included physiological and psychological measurements. Nonrespondents were more likely than respondents to be obese, whereas the menopausal groups showed no mean differences in body mass index. Blood count variables, while being within clinical reference values, showed significant differences between groups. E2 and FSH were associated with the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio. Conclusions: The ERMA study was successful in recruiting and characterizing the menopausal status of a cohort sample of middle-aged women. The significant group differences found in the blood count variables and their associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an early sign of low-grade inflammation that may develop later in life. Key Words: 17b-Estradiol – Blood viscosity – FSH – Leucocyte count – Menopausal status – Neutrophil- to-lymphocyte ratio.fi
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofseriesMenopause: The Journal of The North American Menopause Society
dc.rightsCC BY-NC-ND 4.0
dc.subject.other17b-Estradiol
dc.subject.otherblood viscosity
dc.subject.otherFSH
dc.subject.otherleucocyte count
dc.subject.othermenopausal status
dc.subject.otherneutrophil-to-lymphocyte ratio
dc.titleDesign and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-related differences in blood count
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808223907
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-08-22T09:15:09Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1020-1032
dc.relation.issn1072-3714
dc.relation.numberinseries9
dc.relation.volume25
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber675003
dc.relation.grantnumber675003
dc.relation.grantnumber275323
dc.relation.grantnumber309504
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/675003/EU//PANINI
dc.subject.ysoestradioli
dc.subject.ysovalkosolut
dc.subject.ysoestrogeenit
dc.subject.ysoohjelmoitunut solukuolema
dc.subject.ysovaihdevuodet
dc.subject.ysolihaskunto
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p19425
jyx.subject.urihttp://www.yso.fi/onto/yso/p18721
jyx.subject.urihttp://www.yso.fi/onto/yso/p16792
jyx.subject.urihttp://www.yso.fi/onto/yso/p6280
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p7382
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1097/GME.0000000000001117
dc.relation.funderEuroopan komissiofi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderEuropean Commissionen
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020fi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramMSCA Marie Skłodowska-Curie Actions, H2020en
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis research is supported by the Academy of Finland (VK: Grant nro 275323, EKL: nro 309504), PANINI (SS: Horizon 2020-the Framework Programme for Research and Innovation, Marie Sklodowska-Curie Actions, ITN, ref 15-0667), and the Juho Vainio Foundation (EKL). Financial disclosure/conflicts of interest: None reported.


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