Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone
Jernfors, T., Kesäniemi, J., Lavrinienko, A., Mappes, T., Milinevsky, G., Møller, A. P., Mousseau, T. A., Tukalenko, E., & Watts, P. C. (2018). Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone. Frontiers in Environmental Science, 5, Article 59. https://doi.org/10.3389/fenvs.2017.00095
Published inFrontiers in Environmental Science
© 2018 Jernfors, Kesäniemi, Lavrinienko, Mappes, Milinevsky, Møller, Mousseau, Tukalenko and Watts. This is an open access article distributed under the terms of the Creative Commons License.
Exposure to ionizing radiation (IR) from radionuclides released into the environment can damage DNA. An expected response to exposure to environmental radionuclides, therefore, is initiation of DNA damage response (DDR) pathways. Increased DNA damage is a characteristic of many organisms exposed to radionuclides but expression of DDR genes of wildlife inhabiting an area contaminated by radionuclides is poorly understood. We quantified expression of five central DDR genes Atm, Mre11, p53, Brca1, and p21 in the livers of the bank vole Myodes glareolus that inhabited areas within the Chernobyl Exclusion Zone (CEZ) that differed in levels of ambient radioactivity, and also from control areas outside the CEZ (i.e., sites with no detectable environmental radionuclides) in Ukraine. Expression of these DDR genes did not significantly differ between male and female bank voles, nor among sites within the CEZ. We found a near two-fold upregulation in the DDR initiators Mre11 and Atm in animals collected from the CEZ compared with samples from control sites. As Atm is an important regulator of oxidative stress, our data suggest that antioxidant activity may be a key component of the defense against exposure to environmental radioactivity. ...
Publication in research information system
MetadataShow full item record
Except where otherwise noted, this item's license is described as © 2018 Jernfors, Kesäniemi, Lavrinienko, Mappes, Milinevsky, Møller, Mousseau, Tukalenko and Watts. This is an open access article distributed under the terms of the Creative Commons License.
Showing items with similar title or keywords.
Supplementary data for Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone. Tukalenko, Eugene; Milinevsky, Gennadi; Møller, Anders P; Mousseau, Timothy A; Lavrinienko, Anton; Watts, Phillip; Mappes, Tapio; Kesäniemi, Jenni; Jernfors, ToniElectronic material for Jernfors et al. 2018. Transcriptional Upregulation of DNA Damage Response Genes in Bank Voles (Myodes glareolus) Inhabiting the Chernobyl Exclusion Zone. Frontiers in Environmental Science 5: 95. ...
The effect of chronic low-dose environmental radiation on organ mass of bank voles in the Chernobyl Exclusion Zone Kivisaari, Kati; Boratyński, Zbyszek; Lavrinienko, Anton; Kesäniemi, Jenni; Lehmann, Philipp; Mappes, Tapio (Taylor & Francis, 2020)Purpose: Animals are exposed to environmental ionizing radiation (IR) externally through proximity to contaminated soil and internally through ingestion and inhalation of radionuclides. Internal organs can respond to ...
Fibroblasts from bank voles inhabiting Chernobyl have increased resistance against oxidative and DNA stresses Mustonen, Venla; Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Mappes, Tapio; Watts, Phillip C.; Jurvansuu, Jaana (BioMed Central Ltd., 2018)Background: Elevated levels of environmental ionizing radiation can be a selective pressure for wildlife by producing reactive oxygen species and DNA damage. However, the underlying molecular mechanisms that are affected ...
Chronic Background Radiation Correlates With Sperm Swimming Endurance in Bank Voles From Chernobyl Kivisaari, Kati; Calhim, Sara; Lehmann, Philipp; Boratyński, Zbyszek; Mousseau, Timothy A.; Møller, Anders P.; Mappes, Tapio (Frontiers Media SA, 2022)Sperm quantity and quality are key features explaining intra- and interspecific variation in male reproductive success. Spermatogenesis is sensitive to ionizing radiation and laboratory studies investigating acute effects ...
Mappes, Tapio; Boratynski, Zbigniew; Kivisaari, Kati; Lavrinienko, Anton; Milinevsky, Gennadi; Mousseau, Timothy A.; Møller, Anders P.; Tukalenko, Eugene; Watts, Phillip (Ecological Society of America, 2019)Nuclear accidents underpin the need to quantify the ecological mechanisms which determine injury to ecosystems from chronic low‐dose radiation. Here, we tested the hypothesis that ecological mechanisms interact with ionizing ...