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dc.contributor.authorWaselius, Tomi
dc.contributor.authorPöllänen, Eveliina
dc.contributor.authorWikgren, Jan
dc.contributor.authorPenttonen, Markku
dc.contributor.authorNokia, Miriam
dc.date.accessioned2017-10-31T11:02:45Z
dc.date.available2019-07-30T21:35:23Z
dc.date.issued2017
dc.identifier.citationWaselius, T., Pöllänen, E., Wikgren, J., Penttonen, M., & Nokia, M. (2017). Hippocampal theta phase-contingent memory retrieval in delay and trace eyeblink conditioning. <i>Behavioural Brain Research</i>, <i>337</i>, 264-270. <a href="https://doi.org/10.1016/j.bbr.2017.09.001" target="_blank">https://doi.org/10.1016/j.bbr.2017.09.001</a>
dc.identifier.otherCONVID_27202269
dc.identifier.otherTUTKAID_74891
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/55742
dc.description.abstractHippocampal theta oscillations (3–12 Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace eyeblink conditioning in rabbits suggests that the timing of the conditioned stimulus (CS) in relation to theta phase affects encoding but not retrieval of the memory trace. Here, we directly tested the effects of hippocampal theta phase on memory retrieval in two experiments conducted on adult female New Zealand White rabbits. In Experiment 1, animals were trained in trace eyeblink conditioning followed by extinction, and memory retrieval was tested by presenting the CS at troughs and peaks of the theta cycle during different stages of learning. In Experiment 2, animals were trained in delay conditioning either contingent on a high level of theta or at a random neural state. Conditioning was then followed by extinction conducted either at a random state, contingent on theta trough or contingent on theta peak. Our current results indicate that the phase of theta at CS onset has no effect on the performance of the behavioral learned response at any stage of classical eyeblink conditioning or extinction. In addition, theta-contingent trial presentation does not improve learning during delay eyeblink conditioning. The results are consistent with our earlier findings and suggest that the theta phase alone is not sufficient to affect learning at the behavioral level. It seems that the retrieval of recently acquired memories and consequently performing a learned response is moderated by neural mechanisms other than hippocampal theta.
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.ispartofseriesBehavioural Brain Research
dc.subject.othermuisti
dc.subject.otherclassical conditioning
dc.subject.othermemory
dc.subject.othertheta oscillation
dc.titleHippocampal theta phase-contingent memory retrieval in delay and trace eyeblink conditioning
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201710163995
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-10-16T06:15:10Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange264-270
dc.relation.issn0166-4328
dc.relation.numberinseries0
dc.relation.volume337
dc.type.versionacceptedVersion
dc.rights.copyright© 2017 Elsevier B.V. This is a final draft version of an article whose final and definitive form has been published by Elsevier. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber286384
dc.subject.ysoehdollistuminen
dc.subject.ysooppiminen
dc.subject.ysohippokampus
jyx.subject.urihttp://www.yso.fi/onto/yso/p2942
jyx.subject.urihttp://www.yso.fi/onto/yso/p2945
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
dc.relation.doi10.1016/j.bbr.2017.09.001
dc.relation.funderSuomen Akatemiafi
dc.relation.funderResearch Council of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationWe thank Lauri Viljanto for technical help and Henriikka Huhtamäki for assisting in experiments. The work was supported by the Academy of Finland [grant number 286384 to M.S.N.].
dc.type.okmA1


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