Näytä suppeat kuvailutiedot

dc.contributor.authorBulanova, Daria
dc.contributor.authorIanevski, Aleksandr
dc.contributor.authorBugai, Andrii
dc.contributor.authorAkimov, Yevhen
dc.contributor.authorKuivanen, Suvi
dc.contributor.authorPaavilainen, Henrik
dc.contributor.authorKakkola, Laura
dc.contributor.authorNandania, Jatin
dc.contributor.authorTurunen, Laura
dc.contributor.authorOhman, Tiina
dc.contributor.authorAla-Hongisto, Hanna
dc.contributor.authorPesonen, Hanna M.
dc.contributor.authorKuisma, Marika S.
dc.contributor.authorHonkimaa, Anni
dc.contributor.authorWalton, Emma L.
dc.contributor.authorOksenych, Valentyn
dc.contributor.authorLorey, Martina B.
dc.contributor.authorGuschin, Dmitry
dc.contributor.authorShim, Jungmin
dc.contributor.authorKim, Jinhee
dc.contributor.authorThan, Thoa T.
dc.contributor.authorChang, So Young
dc.contributor.authorHukkanen, Veijo
dc.contributor.authorKulesskiy, Evgeny
dc.contributor.authorMarjomäki, Varpu
dc.contributor.authorJulkunen, Ilkka
dc.contributor.authorNyman, Tuula A.
dc.contributor.authorMatikainen, Sampsa
dc.contributor.authorSaarela, Jani S.
dc.contributor.authorSane, Famara
dc.contributor.authorHober, Didier
dc.contributor.authorGabriel, Gülsah
dc.contributor.authorDe Brabander, Jef K.
dc.contributor.authorMartikainen, Miika
dc.contributor.authorWindisch, Marc P.
dc.contributor.authorMin, Ji-Young
dc.contributor.authorBruzzone, Roberto
dc.contributor.authorAittokallio, Tero
dc.contributor.authorVähä-Koskela, Markus
dc.contributor.authorVapalahti, Olli
dc.contributor.authorPulk, Arto
dc.contributor.authorVelagapudi, Vidya
dc.contributor.authorKainov, Denis E.
dc.date.accessioned2017-10-04T06:50:13Z
dc.date.available2017-10-04T06:50:13Z
dc.date.issued2017
dc.identifier.citationBulanova, D., Ianevski, A., Bugai, A., Akimov, Y., Kuivanen, S., Paavilainen, H., Kakkola, L., Nandania, J., Turunen, L., Ohman, T., Ala-Hongisto, H., Pesonen, H. M., Kuisma, M. S., Honkimaa, A., Walton, E. L., Oksenych, V., Lorey, M. B., Guschin, D., Shim, J., . . . Kainov, D. E. (2017). Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins. <i>Viruses</i>, <i>9</i>(10), Article 271. <a href="https://doi.org/10.3390/v9100271" target="_blank">https://doi.org/10.3390/v9100271</a>
dc.identifier.otherCONVID_27256514
dc.identifier.otherTUTKAID_75181
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/55521
dc.description.abstractViral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases. View Full-Texten
dc.languageeng
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesViruses
dc.subject.otherantiviral agent
dc.subject.otherapoptosis
dc.subject.otherhost response
dc.subject.otherinnate immunity
dc.titleAntiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201710023902
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-10-02T15:15:10Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1999-4915
dc.relation.numberinseries10
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2017 the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysovirustaudit
dc.subject.ysoohjelmoitunut solukuolema
jyx.subject.urihttp://www.yso.fi/onto/yso/p16261
jyx.subject.urihttp://www.yso.fi/onto/yso/p6280
dc.rights.urlhttp://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/v9100271
jyx.fundinginformationThis study was supported by the J&A Erkko foundation (to Denis E. Kainov.), the European Regional Development Fund, the Mobilitas Pluss Project MOBTT39 (to Denis E. Kainov), a University of Helsinki three-year research grant (No. 465/51/2014, to Denis E. Kainov), the Academy of Finland (grant No. SA259725 to Olli Vapalahti), the Sigrid Juselius Foundation (to Olli Vapalahti), the Robert A. Welch Foundation (grant No. I-1422, to Jef K. De Brabander), EA3610 University of Lille 2 and CHRU Lille grants (to Didier Hober), and the Bio&Medical Technology Development Program of the NRF, funded by the Ministry of Science, ICT and Future Planning, Republic of Korea (grant No. 1601-0302, to Ji-Young Min).
dc.type.okmA1


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© 2017 the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License.
Ellei muuten mainita, aineiston lisenssi on © 2017 the Authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License.