Visual processing in patients with age-related macular degeneration performing a face detection test
Vottonen, P., Kaarniranta, K., Pääkkönen, A., & Tarkka, I. (2017). Visual processing in patients with age-related macular degeneration performing a face detection test. Clinical Ophthalmology, 2017(11), 1245-1252. https://doi.org/10.2147/OPTH.S132583
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Clinical OphthalmologyDate
2017Discipline
LiikuntalääketiedeMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöSports and Exercise MedicineCentre for Interdisciplinary Brain ResearchSchool of WellbeingCopyright
© 2017 Vottonen et al. This work is published and licensed by Dove Medical Press Limited, distributed under the terms of a Creative Commons License.
Purpose: People with age-related macular degeneration (AMD) have difficulties in familiar face
recognition and facial expression discrimination. Our aim was to evaluate the visual processing
of faces in AMD patients and whether this would be improved by anti-vascular endothelial
growth factor therapy. This was a prospective interventional cohort study.
Patients: Twelve patients with monocular wet AMD and 6 control subjects were recruited.
Face detection processes were studied using cortical event-related potentials (ERPs). Patients
received 3 bevacizumab intravitreal injections to the single affected eye. At baseline and
4–6 weeks after the last injection, clinical presentation and ERPs of the face task were evaluated.
Face pictures were shown as targets (16.7%) among standard pictures of pixelated faces
in an oddball-type paradigm.
Results: Face pictures elicited well-defined electrical components in occipital and parieto-occipital
cortical areas at baseline and after treatment. The face-specific N170 component was evident in
all subjects with longer peak latency in patients than in controls (170±13 vs 155±14, P=0.032).
Unexpectedly, an early component reflecting unintentional prediction of perceiving a face, that is,
deviance-related negativity, was present in patients and controls. Visual acuity of the affected eye
seemed improved in patients from logarithm of the minimum angle of resolution 0.71 (±0.33) to
0.52 (±0.39) by 119 (±23) days without accompanying significant change in face-specific ERPs.
Conclusions: Monocular wet AMD distinctly influenced face-specific brain electrophysiological
components. However, the anti-vascular endothelial growth factor treatment did not improve
the binocular face detection ability. The EudraCT number of this study is 2012-000765-20.
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Except where otherwise noted, this item's license is described as © 2017 Vottonen et al. This work is published and licensed by Dove Medical Press Limited, distributed under the terms of a Creative Commons License.
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