Effects of resistance training on expression of IGF-I splice variants in younger and older men
Ahtiainen, J., Hulmi, J., Lehti, M., Kraemer, W. J., Nyman, K., Selänne, H., Alen, M., Komulainen, J., Kovanen, V., Mero, A., Philippou, A., Laakkonen, E., & Häkkinen, K. (2016). Effects of resistance training on expression of IGF-I splice variants in younger and older men. European Journal of Sport Science, 16(8), 1055-1063. https://doi.org/10.1080/17461391.2016.1185164
Published inEuropean Journal of Sport Science
DisciplineLiikuntafysiologiaGerontologia ja kansanterveysValmennus- ja testausoppiExercise PhysiologyGerontology and Public HealthScience of Sport Coaching and Fitness Testing
© 2016 European College of Sport Science. This is a final draft version of an article whose final and definitive form has been published by Taylor & Francis. Published in this repository with the kind permission of the publisher.
Insulin-like growth factor-I (IGF-I) and its splice variants Insulin-like growth factor-I isoform Ea (IGF-IEa) and mechano growth factor (MGF) may play an important role in muscular adaptations to resistance training (RT) that may be modulated by ageing. It has been suggested that IGF-I induces cellular responses via AKT8 virus oncogene cellular homolog (Akt) and Extracellular signal-regulated kinase (Erk) signalling pathways. Therefore, resistance exercise-induced changes in skeletal muscle IGF-IEa and MGF messenger ribonucleic acid (mRNA), and MGF, Erk1/2, Akt and p70S6K protein expression were investigated before and after 21 weeks of RT in younger (YM, 20–34 yrs., n = 7) and older men (OM, 51–71 yrs., n = 10). Experimental resistance exercises (RE) of 5 × 10 repetition maximum leg presses were performed pre- and post-RT. Muscle biopsies were obtained before and 48 h after REs, to study the late response to muscle loading. The muscle proteins or mRNAs of interest were not systematically influenced by the REs or RT, except for MGF mRNA expression which was increased (p < .01) following RE before RT in OM. No differences were observed between YM and OM in any variables. This study demonstrated that basal levels or RE-induced responses in skeletal muscle MGF, Erk1/2, Akt and p70S6K protein levels or IGF-IEa and MGF mRNA expression did not differ between YM and OM, nor change systematically due to RT. Thus, ageing appears not to effect expression of the present signalling molecules involved in skeletal muscle hypertrophy. ...
PublisherTaylor & Francis Ltd.; European College of Sport Science
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