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dc.contributor.authorHägg, S.
dc.contributor.authorZhan, Y.
dc.contributor.authorKarlsson, R.
dc.contributor.authorGerritsen, L.
dc.contributor.authorPloner, A.
dc.contributor.authorvan der Lee, S. J.
dc.contributor.authorBroer, L.
dc.contributor.authorDeelen, J.
dc.contributor.authorMarioni, R. E.
dc.contributor.authorWong, A.
dc.contributor.authorLundquist, A.
dc.contributor.authorZhu, G.
dc.contributor.authorHansell, N. K.
dc.contributor.authorSillanpää, Elina
dc.contributor.authorFedko, I. O.
dc.contributor.authorAmin, N. A.
dc.contributor.authorBeekman, M.
dc.contributor.authorCraen, A. J. M. de
dc.contributor.authorDegerman, S.
dc.contributor.authorHarris, S. E.
dc.contributor.authorKan, K.-J.
dc.contributor.authorMartin-Ruiz, C. M.
dc.contributor.authorMontgomery, G. W.
dc.contributor.authorGroup, NeuroCHARGE Cognitive Working
dc.contributor.authorAdolfsson, A. N.
dc.contributor.authorReynolds, C. A.
dc.contributor.authorSamani, N. J.
dc.contributor.authorSuchiman, H. E. D.
dc.contributor.authorViljanen, Anne
dc.contributor.authorvon Zglinicki, T.
dc.contributor.authorWright, M. J.
dc.contributor.authorHottenga, J.-J.
dc.contributor.authorBoomsma, D. I.
dc.contributor.authorRantanen, Taina
dc.contributor.authorKaprio, J. A.
dc.contributor.authorNyholt, D. R.
dc.contributor.authorMartin, N. G.
dc.contributor.authorNyberg, L.
dc.contributor.authorAdolfsson, R.
dc.contributor.authorKuh, D.
dc.contributor.authorStarr, J. M.
dc.contributor.authorDeary, I. J.
dc.contributor.authorSlagboom, P. E.
dc.contributor.authorvan Duijn, C. M.
dc.contributor.authorCodd, V.
dc.contributor.authorPedersen, N. L.
dc.identifier.citationHägg, S., Zhan, Y., Karlsson, R., Gerritsen, L., Ploner, A., van der Lee, S. J., Broer, L., Deelen, J., Marioni, R. E., Wong, A., Lundquist, A., Zhu, G., Hansell, N. K., Sillanpää, E., Fedko, I. O., Amin, N. A., Beekman, M., Craen, A. J. M. D., Degerman, S., . . . Pedersen, N. L. (2017). Short telomere length is associated with impaired cognitive performance in European ancestry cohorts. <i>Translational Psychiatry</i>, <i>7</i>(4), Article e1100. <a href="" target="_blank"></a>
dc.description.abstractThe association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N = 17 052; mean age = 59.2 ± 8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL including seven known genetic variants for TL was calculated, and used in associations with cognitive traits as outcomes in all cohorts. Observational analyses showed that longer telomeres were associated with better scores on DSST (β = 0.051 per s.d.-increase of TL; 95% confidence interval (CI): 0.024, 0.077; P = 0.0002), and MMSE (β = 0.025; 95% CI: 0.002, 0.047; P = 0.03), and faster STROOP (β = − 0.053; 95% CI: − 0.087, − 0.018; P = 0.003). Effects for DSST were stronger in APOE ε4 non-carriers (β = 0.081; 95% CI: 0.045, 0.117; P = 1.0 × 10 − 5 ), whereas carriers performed better in STROOP (β = − 0.074; 95% CI: − 0.140, − 0.009; P = 0.03). Causal associations were found for STROOP only (β = − 0.598 per s.d.-increase of TL; 95% CI: − 1.125, − 0.072; P = 0.026), with a larger effect in ε4-carriers (β = − 0.699; 95% CI: − 1.330, − 0.069; P = 0.03). Two-sample replication analyses using CHARGE summary statistics showed causal effects between TL and general cognitive function and DSST, but not with STROOP. In conclusion, we suggest causal effects from longer TL on better cognitive performance, where APOE ε4-carriers might be at differential risk.
dc.publisherNature Publishing Group
dc.relation.ispartofseriesTranslational Psychiatry
dc.subject.othercognitive performance
dc.subject.othertelomere length
dc.subject.othergenetic risk score
dc.titleShort telomere length is associated with impaired cognitive performance in European ancestry cohorts
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.coarjournal article
dc.rights.copyright© the Authors, 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.

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© the Authors, 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © the Authors, 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.