dc.contributor.author | Pyoriä, Lari | |
dc.contributor.author | Toppinen, Mari | |
dc.contributor.author | Mäntylä, Elina | |
dc.contributor.author | Hedman, Lea | |
dc.contributor.author | Aaltonen, Leena-Maija | |
dc.contributor.author | Vihinen-Ranta, Maija | |
dc.contributor.author | Ilmarinen, Taru | |
dc.contributor.author | Söderlund-Venermo, Maria | |
dc.contributor.author | Hedman, Klaus | |
dc.contributor.author | Perdomo, Maria F. | |
dc.date.accessioned | 2017-04-07T10:39:38Z | |
dc.date.available | 2017-04-07T10:39:38Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Pyoriä, L., Toppinen, M., Mäntylä, E., Hedman, L., Aaltonen, L.-M., Vihinen-Ranta, M., Ilmarinen, T., Söderlund-Venermo, M., Hedman, K., & Perdomo, M. F. (2017). Extinct type of human parvovirus B19 persists in tonsillar B cells. <i>Nature Communications</i>, <i>8</i>, Article 14930. <a href="https://doi.org/10.1038/ncomms14930" target="_blank">https://doi.org/10.1038/ncomms14930</a> | |
dc.identifier.other | CONVID_26937183 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/53530 | |
dc.description.abstract | Parvovirus B19 (B19V) DNA persists lifelong in human tissues, but the cell type harbouring it
remains unclear. We here explore B19V DNA distribution in B, Tand monocyte cell lineages of
recently excised tonsillar tissues from 77 individuals with an age range of 2–69 years. We
show that B19V DNA is most frequent and abundant among B cells, and within them we find
a B19V genotype that vanished from circulation 440 years ago. Since re-infection or
re-activation are unlikely with this virus type, this finding supports the maintenance of
pathogen-specific humoral immune responses as a consequence of B-cell long-term survival
rather than continuous replenishment of the memory pool. Moreover, we demonstrate the
mechanism of B19V internalization to be antibody dependent in two B-cell lines as well as in
ex vivo isolated tonsillar B cells. This study provides direct evidence for a cell type accountable
for B19V DNA tissue persistence. | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation.ispartofseries | Nature Communications | |
dc.subject.other | parvovirus B19 | |
dc.subject.other | B cells | |
dc.subject.other | cell type harbouring | |
dc.subject.other | virus types | |
dc.title | Extinct type of human parvovirus B19 persists in tonsillar B cells | |
dc.type | research article | |
dc.identifier.urn | URN:NBN:fi:jyu-201704051907 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Nanoscience Center | fi |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.contributor.oppiaine | Nanoscience Center | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2017-04-05T12:15:03Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 2041-1723 | |
dc.relation.numberinseries | 0 | |
dc.relation.volume | 8 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © the Authors, 2017. This is an open access article distributed under the terms of a Creative Commons License. | |
dc.rights.accesslevel | openAccess | fi |
dc.type.publication | article | |
dc.subject.yso | solut | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2409 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1038/ncomms14930 | |
dc.type.okm | A1 | |