University of Jyväskylä | JYX Digital Repository

  • English  | Give feedback |
    • suomi
    • English
 
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  • JYX
  • Artikkelit
  • Matemaattis-luonnontieteellinen tiedekunta
  • View Item
JYX > Artikkelit > Matemaattis-luonnontieteellinen tiedekunta > View Item

A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards

ThumbnailFinal Draft
View/Open
331.6 Kb

Downloads:  
Show download detailsHide download details  
Ngumba, E., Kosunen, P., Gachanja, A., & Tuhkanen, T. (2016). A multiresidue analytical method for trace level determination of antibiotics and antiretroviral drugs in wastewater and surface water using SPE-LC-MS/MS and matrix-matched standards. Analytical Methods, 8(37), Article 6720-6729. https://doi.org/10.1039/C6AY01695B
Published in
Analytical Methods
Authors
Ngumba, Elijah |
Kosunen, Päivi |
Gachanja, Anthony |
Tuhkanen, Tuula
Date
2016
Discipline
YmpäristötiedeEnvironmental Science
Copyright
© The Royal Society of Chemistry 2016. This is a final draft version of an article whose final and definitive form has been published by RSC. Published in this repository with the kind permission of the publisher.

 
An analytical method for simultaneous determination of seven commonly used antibiotics and three antiretrovirals in surface water and urban wastewater at the ng L−1 level has been developed. The method involves concentration and clean-up by solid phase extraction (SPE) followed by identification and quantification by liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). The use of matrix-matched calibration curves constructed by spiking surface water was evaluated for quantification and compared with the internal standard method using isotopically labelled compounds. The method gave absolute recoveries of 41–116% with most of the compounds having recoveries >50%. The LOQs ranged from 5 to 63 ng L−1 allowing for the determination of the analytes at trace levels in the environmental samples considered. The difference in the quantification results obtained using surface water matrix-matched standards and internal standards was within a ±20% margin. The method provides an affordable and relatively fast alternative with acceptable accuracy and precision. The method was applied to study the occurrence of the target analytes in the surface water of Lake Päijänne and wastewater from the Jyväskylä wastewater treatment plant (WWTP) in Central Finland. All target compounds were detected in the WWTP streams with concentrations ranging between 10 and 570 ng L−1 while low ng L−1 levels were measured for some of the analytes in surface waters. The results institute the need for further monitoring in other WWTP streams and receiving waters as well as improvements of the wastewater treatment process with the aim of minimizing the pharmaceutical load in the effluents. ...
Publisher
RSC Publications
ISSN Search the Publication Forum
1759-9660
Keywords
wastewater antiretroviral drugs solid phase extraction liquid chromatography tandem mass spectrometry pintavesi antibiootit
DOI
https://doi.org/10.1039/C6AY01695B
URI

http://urn.fi/URN:NBN:fi:jyu-201611184665

Publication in research information system

https://converis.jyu.fi/converis/portal/detail/Publication/26254984

Metadata
Show full item record
Collections
  • Matemaattis-luonnontieteellinen tiedekunta [5292]

Related items

Showing items with similar title or keywords.

  • Occurrence of antibiotics and antiretroviral drugs in source-separated urine, groundwater, surface water and wastewater in the peri-urban area of Chunga in Lusaka, Zambia 

    Ngumba, Elijah; Gachanja, Anthony; Nyirenda, James; Maldonado, Johanna; Tuhkanen, Tuula (Water Research Commission, 2020)
    Recently, there has been an increased interest in bridging the knowledge gap in the occurrence and fate of pharmaceuticals in African urban water cycles. In this study, the occurrence of 7 antibiotics and 3 antiretrovirals in ...
  • Contamination of Surface Water and River Sediments by Antibiotic and Antiretroviral Drug Cocktails in Low and Middle-Income Countries : Occurrence, Risk and Mitigation Strategies 

    Kairigo, Pius; Ngumba, Elijah; Sundberg, Lotta-Riina; Gachanja, Anthony; Tuhkanen, Tuula (MDPI, 2020)
    Presence of antimicrobial cocktails in the hydrological cycles is of interest because of their potential to mediate antimicrobial resistance within the natural environment. In this study, we determined the concentrations ...
  • Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments 

    Kairigo, Pius; Ngumba, Elijah; Sundberg, Lotta-Riina; Gachanja, Anthony; Tuhkanen, Tuula (Elsevier, 2020)
    Active pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to ...
  • Occurrence and control of selected antibiotics and antiretroviral drugs in urban hydrological cycles 

    Ngumba, Elijah (University of Jyväskylä, 2018)
  • Mass loading, distribution, and removal of antibiotics and antiretroviral drugs in selected wastewater treatment plants in Kenya 

    Muriuki, Cecilia; Kairigo, Pius; Home, Patrick; Ngumba, Elijah; Raude, James; Gachanja, Anthony; Tuhkanen, Tuula (Elsevier BV, 2020)
    The discharge of active pharmaceutical ingredients (APIs) into the aquatic environment from wastewater effluents is a concern in many countries. Although many studies have been conducted to evaluate the APIs removal ...
  • Browse materials
  • Browse materials
  • Articles
  • Conferences and seminars
  • Electronic books
  • Historical maps
  • Journals
  • Tunes and musical notes
  • Photographs
  • Presentations and posters
  • Publication series
  • Research reports
  • Research data
  • Study materials
  • Theses

Browse

All of JYXCollection listBy Issue DateAuthorsSubjectsPublished inDepartmentDiscipline

My Account

Login

Statistics

View Usage Statistics
  • How to publish in JYX?
  • Self-archiving
  • Publish Your Thesis Online
  • Publishing Your Dissertation
  • Publication services

Open Science at the JYU
 
Data Protection Description

Accessibility Statement

Unless otherwise specified, publicly available JYX metadata (excluding abstracts) may be freely reused under the CC0 waiver.
Open Science Centre