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dc.contributor.authorRintala, Aki
dc.contributor.authorHäkkinen, Arja
dc.contributor.authorPaltamaa, Jaana
dc.date.accessioned2016-11-18T09:18:02Z
dc.date.available2017-06-30T21:45:06Z
dc.date.issued2016
dc.identifier.citationRintala, A., Häkkinen, A., & Paltamaa, J. (2016). Ten-year follow-up of health-related quality of life among ambulatory persons with multiple sclerosis at baseline. <i>Quality of Life Research</i>, <i>25</i>(12), 3119-3127. <a href="https://doi.org/10.1007/s11136-016-1347-x" target="_blank">https://doi.org/10.1007/s11136-016-1347-x</a>
dc.identifier.otherCONVID_26102368
dc.identifier.otherTUTKAID_70565
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/51920
dc.description.abstractPurpose The aim of this 10-year follow-up study was to determine changes in health-related quality of life (HRQoL) over time among ambulatory persons with MS (PwMS) at the baseline using generic and disease-specific instruments. Methods Of 109 independently walking PwMS included in a population-based study in 2002, 77 (70.6 %) were re-assessed in 2012. HRQoL was captured using the 36-Item Short Form Survey Instrument (RAND-36), 15D instrument (15D), and the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Repeated-measures ANOVA and effect size (ES) calculations (Cohen’s d) were used in the statistical analysis. Results The RAND-36 physical health composite score (p = 0.003, ES = 0.26) and 15D total score (p = 0.012, ES = 0.25) declined from the baseline levels. In particular, lower scores were observed on the RAND-36 scales of physical functioning (p = 0.001, ES = 0.27), pain (p = 0.020, ES = 0.25), and general health perceptions (p = 0.002, ES = 0.36), on the MSQOL-54 scales of physical functioning (p = 0.001, ES = 0.27), pain (p = 0.040, ES = 0.21), sexual functioning (p = 0.003, ES = 0.43), and satisfaction with sexual functioning (p = 0.012, ES = 0.38), and in the 15D dimensions of mobility (p = 0.004, ES = 0.31) and sexual functioning (p ≤ 0.001, ES = 0.59). Improvement was observed on the RAND-36 scale of social functioning (p = 0.049, ES = 0.25). The other composite scores, scales, and dimensions remained unchanged. Conclusion The results of this study suggest that ambulatory PwMS at baseline reported reduced HRQoL in physical functioning after a 10-year follow-up period, while emotional well-being was maintained and social functioning improved. The scores in the other HRQoL dimensions and scales remained unchanged. More long-term population-based studies are needed to precisely determine the development of HRQoL among PwMS.
dc.language.isoeng
dc.publisherSpringer Netherlands; International Society for Quality of Life Studies
dc.relation.ispartofseriesQuality of Life Research
dc.subject.otherpatient-reported outcomes
dc.titleTen-year follow-up of health-related quality of life among ambulatory persons with multiple sclerosis at baseline
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201611114613
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineFysioterapiafi
dc.contributor.oppiainePhysiotherapyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-11-11T13:15:02Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange3119-3127
dc.relation.issn0962-9343
dc.relation.numberinseries12
dc.relation.volume25
dc.type.versionacceptedVersion
dc.rights.copyright© Springer International Publishing Switzerland 2016. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoMS-tauti
dc.subject.ysoterveys
dc.subject.ysoelämänlaatu
jyx.subject.urihttp://www.yso.fi/onto/yso/p4226
jyx.subject.urihttp://www.yso.fi/onto/yso/p2762
jyx.subject.urihttp://www.yso.fi/onto/yso/p10759
dc.relation.doi10.1007/s11136-016-1347-x
dc.type.okmA1


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