Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
Abstract
Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how
insufficient sleep contributes to these diseases are scarce. These questions were addressed using two
approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with
objective verification of sleep amount, and two independent epidemiological cohorts (altogether
2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and
serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol
transporters and increased expression in pathways involved in inflammatory responses in both
paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts
among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep
restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and
cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward
potentially higher risk for cardiometabolic diseases.
Main Authors
Format
Articles
Research article
Published
2016
Series
Subjects
Publication in research information system
Publisher
Nature Publishing Group
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201605062439Use this for linking
Review status
Peer reviewed
ISSN
2045-2322
DOI
https://doi.org/10.1038/srep24828
Language
English
Published in
Scientific Reports
Citation
- Aho, V., Ollila, H. M., Kronholm, E., Bondia-Pons, I., Soininen, P., Kangas, A. J., Hilvo, M., Seppälä, I., Kettunen, J., Oikonen, M., Raitoharju, E., Hyötyläinen, T., Kähönen, M., Viikari, J. S., Härmä, M., Sallinen, M., Olkkonen, V. M., Alenius, H., Jauhiainen, M., . . . Porkka-Heiskanen, T. (2016). Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Scientific Reports, 6, Article 24828. https://doi.org/10.1038/srep24828
Copyright© the Authors, 2016. This is an open access article published by Nature Publishing Group and distributed under a Creative Commons Attribution 4.0 International License.