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dc.contributor.authorCREAM consortium
dc.contributor.authorPärssinen, Olavi
dc.date.accessioned2016-04-29T05:44:47Z
dc.date.available2016-04-29T05:44:47Z
dc.date.issued2015
dc.identifier.citationCREAM consortium. (2015). Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium. <em>Human Genetics</em>, 134 (2), 131-146. <a href="http://dx.doi.org/10.1007/s00439-014-1500-y">doi:10.1007/s00439-014-1500-y</a>
dc.identifier.otherTUTKAID_63662
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49595
dc.description.abstractTo identify genetic variants associated with refractive astigmatism in the general population, metaanalyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged <25 years (4 cohorts, N = 5,640); and all independent individuals from the above three samples combined with a sample of Chinese subjects aged <25 years (N = 45,931). Participants were classified as cases with refractive astigmatism if the average cylinder power in their two eyes was at least 1.00 diopter and as controls otherwise. Genome-wide association analysis was carried out for each cohort separately using logistic regression. Meta-analysis was conducted using a fixed effects model. In the older European group the most strongly associated marker was downstream of the neurexin-1 (NRXN1) gene (rs1401327, P = 3.92E−8). No other region reached genome-wide significance, and association signals were lower for the younger European group and Asian group. In the meta-analysis of all cohorts, no marker reached genome-wide significance: The most strongly associated regions were, NRXN1 (rs1401327, P = 2.93E−07), TOX (rs7823467, P = 3.47E−07) and LINC00340 (rs12212674, P = 1.49E−06). For 34 markers identified in prior GWAS for spherical equivalent refractive error, the beta coefficients for genotype versus spherical equivalent, and genotype versus refractive astigmatism, were highly correlated (r = −0.59, P = 2.10E−04). This work revealed no consistent or strong genetic signals for refractive astigmatism; however, the TOX gene region previously identified in GWAS for spherical equivalent refractive error was the second most strongly associated region. Analysis of additional markers provided evidence supporting widespread genetic co-susceptibility for spherical and astigmatic refractive errors.
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesHuman Genetics
dc.subject.otherastigmatism
dc.subject.otherhuman genetics
dc.titleGenome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201604272341
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-04-27T12:15:05Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange131-146
dc.relation.issn0340-6717
dc.relation.volume134
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2014. This is an open access article published by Springer and distributed under the terms of the Creative Commons Attribution License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s00439-014-1500-y


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© The Author(s) 2014. This is an open access article published by Springer and distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © The Author(s) 2014. This is an open access article published by Springer and distributed under the terms of the Creative Commons Attribution License.