Lifespan and skeletal muscle properties the effects of genetic background, physical activity and aging
Abstract
Obesity and metabolic disorders have become a notable world-wide epidemic.
The pathogenesis of metabolic diseases, such as metabolic syndrome and type 2
diabetes, has begun to negatively affect life expectancy of current generations.
Low aerobic capacity has shown to be a strong predictor of mortality both in
rodents and humans. Exercise is known to increase an individual’s aerobic
capacity; interestingly, recent studies have suggested that genetic background
may play a significant role in the physical activity level of an individual. The
purpose of this study was to investigate the role of genetic background and
physical activity on skeletal muscle properties, metabolism and lifespan. The
study consisted of three parts: (1) a cross-sectional voluntary running intervention
in high-capacity runner (HCR) and low-capacity runner (LCR) rats, (2) a
longitudinal voluntary running intervention in HCR and LCR rats, and (3) a long-
term follow-up study with physical activity discordant human twins. Our study
showed that low intrinsic aerobic capacity is associated with fast muscular fatigue
and slow metabolic recovery after maximal muscle contractions. At the whole-
body level, low intrinsic aerobic capacity was linked to low body temperature,
which may play a role in the onset of gaining extra weight and, thus, developing
metabolic disorders. High intrinsic aerobic capacity in turn was associated with
elevated SIRT3 protein level in skeletal muscle, which is possibly linked to
increased lifespan. Nevertheless, vigorous physical activity commenced at adult
age did not reduce mortality or increase lifespan in rodents. High long-term
participation in vigorous leisure-time physical activity did predict significantly
reduced mortality in dizygotic twins; however, there was no difference in the
lifespan of monozygotic twins that are genetically identical. HCRs were more
physically active both in control and voluntary running groups when compared
to corresponding LCR groups. Also, the persistent discordances in participation of
vigorous physical activity were significantly more common in dizygotic twin
pairs than in monozygotic pairs stating that genes have an influence on the
persistent voluntary participation in vigorous leisure-time physical activity. Our
results indicated that genetic predisposition plays a significant role in exercise
participation, hence, genetic pleiotropy may partly explain the associations
observed previously between high physical activity and mortality.
Main Author
Format
Theses
Doctoral thesis
Published
2016
Series
Subjects
ISBN
978-951-39-6604-1
Publisher
University of Jyväskylä
The permanent address of the publication
https://urn.fi/URN:ISBN:978-951-39-6604-1Use this for linking
ISSN
0356-1070
Language
English
Published in
Studies in sport, physical education and health
Contains publications
- Article I: Torvinen, S.,Silvennoinen, M., Piitulainen, H., Närväinen, J., Tuunanen, P., Gröhn, O., L., M., Koch, L.G., Britton, S.L. & Kainulainen, H. 2012. Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions. PloS One 7 (11), e48345. Please see.
- Article II: Karvinen, S., Waller, K., Silvennoinen, M., Koch, L.G., Britton, S.L., Kaprio, J., Kainulainen, H. & Kujala, U.M. 2015. Physical activity in adulthood: genes and mortality. Scientific Reports. 15;5:18259. DOI: 10.1038/srep18259
- Article III: Karvinen, S., Silvennoinen, M., Vainio, P., Sistonen, L., M., Koch, L.G., Britton, S.L. & Kainulainen, H. 2016. Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. Experimental Gerontology 79: 46–54 . DOI: 10.1016/j.exger.2016.03.015 .
- Article IV: Karvinen, S., Silvennoinen, M., Ma, H., Törmäkangas, T., Rantalainen, T., Rinnankoski-Tuikka, R., Lensu, S., Koch, L.G., Britton, S.L., & Kainulainen, H. 2016. Voluntary running aids to maintain high thermogenesis in rats bred for high aerobic capacity. Submitted for publication.