Näytä suppeat kuvailutiedot

dc.contributor.authorWaller, Katja
dc.contributor.authorKujala, Urho
dc.contributor.authorRantanen, Taina
dc.contributor.authorKauppinen, Markku
dc.contributor.authorSilventoinen, Karri
dc.contributor.authorKoskenvuo, Markku
dc.contributor.authorKaprio, Jaakko
dc.date.accessioned2016-03-24T12:16:20Z
dc.date.available2016-03-24T12:16:20Z
dc.date.issued2010
dc.identifier.citationWaller, K., Kujala, U., Rantanen, T., Kauppinen, M., Silventoinen, K., Koskenvuo, M., & Kaprio, J. (2010). Physical activity, morbidity and mortality in twins: a 24-year prospective follow-up. <i>Eur J Epidemiol</i>, <i>25</i>, 731-739. <a href="https://doi.org/10.1007/s10654-010-9493-x" target="_blank">https://doi.org/10.1007/s10654-010-9493-x</a>
dc.identifier.otherCONVID_19919120
dc.identifier.otherTUTKAID_42072
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/49198
dc.description.abstractThe aim of this study was to find out whether persistent leisure-time physical activity, adjusted for genetic liability and childhood experiences, protect against occurrence of specific chronic diseases and all-cause mortality. Study design was a 24-year prospective follow-up after 6-year physical activity discordance in twin pairs. From 5,663 healthy adult twin pairs, 146 pairs (including 29 mozygotic) discordant for both intensity and volume of leisure physical activity at baseline in both 1975 and 1981 were systematically identified. Mortality and occurrence of chronic diseases (diabetes, hypertension, coronary heart disease defined according to reimbursable medication status) were followed for the period 1.1.1983–31.12.2006 for mortality and 1.1.1983–31.12.2004 for diseases. By end of follow-up, 19 inactive and 10 active co-twins had died. In the whole sample, HR of death adjusted for social class was 2.08 (95% CI 1.06–4.09) for inactive vs. active co-twins, the HR being 2.67 (95% CI 1.15–6.20) among DZ pairs with no mortality difference among the smaller number of discordant MZ pairs. The reimbursable medication analyses showed a tendency of higher risk for inactive vs. active co-twins. Among DZ pairs, HR of diabetes medication adjusted for social class was 2.73 (95% CI 0.62–12.00) and HR of hypertension medication was 2.14 (95% CI 0.94–4.89). This study supports the earlier findings that physical activity is associated with reduced mortality. However the difference was seen only in DZ pairs and therefore some residual genetic confounding effects on mortality cannot be excluded.
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesEur J Epidemiol
dc.subject.otherphysical activity
dc.subject.othermorbidity
dc.titlePhysical activity, morbidity and mortality in twins: a 24-year prospective follow-up
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201603241936
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2016-03-24T07:15:02Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange731-739
dc.relation.issn0393-2990 (print version)/1573-7284 (electronic version)
dc.relation.volume25
dc.type.versionacceptedVersion
dc.rights.copyright© Springer Science+Business Media B.V. 2010. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoliikunta
dc.subject.ysoperimä
dc.subject.ysoperiytyvyys
dc.subject.ysosairaudet
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p8862
jyx.subject.urihttp://www.yso.fi/onto/yso/p9515
jyx.subject.urihttp://www.yso.fi/onto/yso/p2633
dc.relation.doi10.1007/s10654-010-9493-x
dc.type.okmA1


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Näytä suppeat kuvailutiedot