Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on B. anthracis.
Kan, S., Fornelos Martins, N., Schuch, R., & Fischetti, V. (2013). Identification of a ligand on the Wip1 bacteriophage highly specific for a receptor on B. anthracis.. Journal of Bacteriology, 195(19), 4355-64. https://doi.org/10.1128/JB.00655-13
Julkaistu sarjassa
Journal of BacteriologyPäivämäärä
2013Oppiaine
Solu- ja molekyylibiologiaBiologisten vuorovaikutusten huippututkimusyksikköCell and Molecular BiologyCentre of Excellence in Biological Interactions ResearchTekijänoikeudet
© 2013, American Society for Microbiology. Published in this repository with the kind permission of the publisher.
Tectiviridae is a family of tailless bacteriophages with Gram-negative and Gram-positive hosts. The family model PRD1 and its
close relatives all infect a broad range of enterobacteria by recognizing a plasmid-encoded conjugal transfer complex as a receptor.
In contrast, tectiviruses with Gram-positive hosts are highly specific to only a few hosts within the same bacterial species.
The cellular determinants that account for the observed specificity remain unknown. Here we present the genome sequence of
Wip1, a tectivirus that infects the pathogen Bacillus anthracis. The Wip1 genome is related to other tectiviruses with Gram-positive
hosts, notably, AP50, but displays some interesting differences in its genome organization. We identified Wip1 candidate
genes for the viral spike complex, the structure located at the capsid vertices and involved in host receptor binding. Phage adsorption
and inhibition tests were combined with immunofluorescence microscopy to show that the Wip1 gene product p23 is a
receptor binding protein. His-p23 also formed a stable complex with p24, a Wip1 protein of unknown function, suggesting that
the latter is involved with p23 in host cell recognition. The narrow host range of phage Wip1 and the identification of p23 as a
receptor binding protein offer a new range of suitable tools for the rapid identification of B. anthracis.
...
Julkaisija
American Society for MicrobiologyISSN Hae Julkaisufoorumista
0021-9193Asiasanat
Alkuperäislähde
http://jb.asm.org/content/early/2013/07/22/JB.00655-13.longJulkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/22539755
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