Conformational equilibrium in supramolecular chemistry: Dibutyltriuret case
Mroczyńska, K., Kaczorowska, M., Kolehmainen, E., Grubecki, I., Pietrzak, M., & Ośmiałowski, B. (2015). Conformational equilibrium in supramolecular chemistry: Dibutyltriuret case. Beilstein Journal of Organic Chemistry, 11, 2105-2116. doi:10.3762/bjoc.11.227
Published inBeilstein Journal of Organic Chemistry
© 2015 Mroczyńska et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License.
The association of substituted benzoates and naphthyridine dianions was used to study the complexation of dibutyltriuret. The title molecule is the simplest molecule able to form two intramolecular hydrogen bonds. The naphthyridine salt was used to break two intramolecular hydrogen bonds at a time while with the use of substituted benzoates the systematic approach to study association was achieved. Both, titrations and variable temperature measurements shed the light on the importance of conformational equilibrium and its influence on association in solution. Moreover, the associates were observed by mass spectrometry. The DFT-based computations for complexes and single bond rotational barriers supports experimental data and helps understanding the properties of multiply hydrogen bonded complexes.