Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection
Mäntylä, E., Niskanen, E., Ihalainen, T., & Vihinen-Ranta, M. (2015). Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection. Journal of Virology, 89 (22), 11706-11710. doi:10.1128/JVI.01608-15
Published inJournal of Virology
DisciplineSolu- ja molekyylibiologia
© 2015, American Society for Microbiology. Published in this repository with the kind permission of the publisher.
Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the late-stage infection.