Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection
Abstract
Canine parvovirus (CPV) infection induces reorganization of nuclear structures. Our studies indicated that late-stage infection
induces accumulation of nuclear pore complexes (NPCs) and lamin B1 concomitantly with a decrease of lamin A/C levels on the
apical side of the nucleus. Newly formed CPV capsids are located in close proximity to NPCs on the apical side. These results
suggest that parvoviruses cause apical enrichment of NPCs and reorganization of nuclear lamina, presumably to facilitate the
late-stage infection.
Main Authors
Format
Articles
Research article
Published
2015
Series
Subjects
Publication in research information system
Publisher
American Society for Microbiology
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201511023548Use this for linking
Review status
Peer reviewed
ISSN
0022-538X
DOI
https://doi.org/10.1128/JVI.01608-15
Language
English
Published in
Journal of Virology
Citation
- Mäntylä, E., Niskanen, E. A., Ihalainen, T. O., & Vihinen-Ranta, M. (2015). Reorganization of Nuclear Pore Complexes and the Lamina in Late-Stage Parvovirus Infection. Journal of Virology, 89(22), 11706-11710. https://doi.org/10.1128/JVI.01608-15
License
Copyright© 2015, American Society for Microbiology. Published in this repository with the kind permission of the publisher.