Hippocampal theta activity, learning and behavioral tendencies
Trace eyeblink conditioning is a method that models a declarative, awareness-dependent form of learning. Hippocampal theta activity, an approximately 3.5 - 8.5 Hz oscillatory pattern in rabbits, has been associated with learning-related phenomena: arousal, attentional processes and association forming. In some studies theta-contingent training, given during a brain state rich in hippocampal theta oscillation, has improved the initial learning in trace eyeblink conditioning. However, other laboratories have failed to replicate this effect. This study explored the effects of theta-contingent conditioning and extinction on learning, and the connection between the magnitude of spontaneous hippocampal theta activity and the behavioral tendencies or individual dispositions of a subject. In this study, Open Field test (OFT) was used to measure behavioral tendencies. Spontaneous hippocampal theta ratio was recorded, and theta-contingent conditioning was performed in three groups: high (T+) and low-theta training (T-) and yoked controls (Y). Unexpectedly, spontaneous hippocampal theta activity did not correlate significantly with the OFT variables. Moreover, while the amount of conditioned responses (CRs) increased as a function of training, the training group had no effect on the learning rate. However, the T- group had the highest proportion of subjects that reached the 60-% learning criterion, and the mean CR% in the best session was significantly higher in the T- group than in the T+ group. In extinction, the T+ group learned significantly faster than the Y group. When classifying the subjects as active versus inactive based on the OFT, T- training significantly improved the learning rate of only the active subjects. The results show that high-theta training did not improve learning in trace eyeblink conditioning, and suggest that theta-contingent training may affect differently subjects with distinct behavioral tendencies. ...
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Raussi, Pekka (2014)
Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits Nokia, Miriam; Penttonen, Markku; Wikgren, Jan (Society for Neuroscience, 2010)There are at least two distinct oscillatory states of the hippocampus that are related to distinct behavioral patterns. Theta (4–12 Hz) oscillation has been suggested to indicate selective attention during which the animal ...
Waselius, Tomi; Pöllänen, Eveliina; Wikgren, Jan; Penttonen, Markku; Nokia, Miriam (Elsevier BV, 2017)Hippocampal theta oscillations (3–12 Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace ...
Hippocampal theta activity is selectively associated with contingency detection but not discrimination in rabbit discrimination-reversal eyeblink conditioning Nokia, Miriam; Wikgren, Jan (Wiley, 2010)The relative power of the hippocampal theta-band (∼6 Hz) activity (theta ratio) is thought to reflect a distinct neural state and has been shown to affect learning rate in classical eyeblink conditioning in rabbits. We ...
Nokia, Miriam (University of Jyväskylä, 2009)