Näytä suppeat kuvailutiedot

dc.contributor.authorNiskanen, Einari A
dc.contributor.authorHytönen, Vesa P
dc.contributor.authorGrapputo, Alessandro
dc.contributor.authorNordlund, Henri R
dc.contributor.authorKulomaa, Markku S
dc.contributor.authorLaitinen, Olli H
dc.date.accessioned2012-11-23T11:20:39Z
dc.date.available2012-11-23T11:20:39Z
dc.date.issued2005fi
dc.identifier.citationNiskanen, E., Hytönen, V., Grapputo, A., Nordlund, H., Kulomaa, M., & Laitinen, O. (2005). Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family. BMC Genomics, (6), 41. doi:10.1186/1471-2164-6-41fi
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2164-6-41
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/40417
dc.description.abstractBackground A chicken egg contains several biotin-binding proteins (BBPs), whose complete DNA and amino acid sequences are not known. In order to identify and characterise these genes and proteins we studied chicken cDNAs and genes available in the NCBI database and chicken genome database using the reported N-terminal amino acid sequences of chicken egg-yolk BBPs as search strings. Results Two separate hits showing significant homology for these N-terminal sequences were discovered. For one of these hits, the chromosomal location in the immediate proximity of the avidin gene family was found. Both of these hits encode proteins having high sequence similarity with avidin suggesting that chicken BBPs are paralogous to avidin family. In particular, almost all residues corresponding to biotin binding in avidin are conserved in these putative BBP proteins. One of the found DNA sequences, however, seems to encode a carboxy-terminal extension not present in avidin. Conclusion We describe here the predicted properties of the putative BBP genes and proteins. Our present observations link BBP genes together with avidin gene family and shed more light on the genetic arrangement and variability of this family. In addition, comparative modelling revealed the potential structural elements important for the functional and structural properties of the putative BBP proteins.fi
dc.language.isoeng
dc.publisherBioMed Central (BMC)
dc.relation.ispartofseriesBMC Genomics
dc.subject.otherBBP
dc.subject.otheravidiini
dc.subject.otherbiotiini
dc.subject.otheravidin
dc.subject.otherbiotin
dc.titleChicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family
dc.typeArticle
dc.identifier.urnURN:NBN:fi:jyu-201804202295
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosThe Department of Biological and Environmental Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doidoi:10.1186/1471-2164-6-41
dc.date.updated2012-11-15T15:00:13Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1471-2164
dc.relation.issn1471-2164
dc.type.versionpublishedVersion
dc.rights.copyright© 2005 Niskanen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/2.0


Aineistoon kuuluvat tiedostot

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Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

© 2005 Niskanen et al; licensee BioMed Central Ltd. 


This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Ellei muuten mainita, aineiston lisenssi on © 2005 Niskanen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.