Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family
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Niskanen, E., Hytönen, V., Grapputo, A., Nordlund, H., Kulomaa, M., & Laitinen, O. (2005). Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family. BMC Genomics, (6), 41. doi:10.1186/1471-2164-6-41
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2005Copyright
© 2005 Niskanen et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background
A chicken egg contains several biotin-binding proteins (BBPs), whose complete DNA and amino acid sequences are not known. In order to identify and characterise these genes and proteins we studied chicken cDNAs and genes available in the NCBI database and chicken genome database using the reported N-terminal amino acid sequences of chicken egg-yolk BBPs as search strings.
Results
Two separate hits showing significant homology for these N-terminal sequences were discovered. For one of these hits, the chromosomal location in the immediate proximity of the avidin gene family was found. Both of these hits encode proteins having high sequence similarity with avidin suggesting that chicken BBPs are paralogous to avidin family. In particular, almost all residues corresponding to biotin binding in avidin are conserved in these putative BBP proteins. One o
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License
Except where otherwise noted, this item's license is described as © 2005 Niskanen et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.