Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties
Abstract
The reaction of 3-aminopropylamide of cholic acid with CS₂ produced a bile acid derivative of dithiocarbamic acid which further formed an ammonium salt with another molecule of 3-aminopropylamide of cholic acid. The cationic 3-ammonium propylamide of cholic acid did not react further with CS₂ and the formed salt was stable in the reaction mixture, even when excess CS₂ was used. When the reaction was carried out in the presence of aqueous sodium hydroxide, only the bile acid derivative of sodium dithiocarbamate was formed. The dithiocarbamate derivatives were characterized by ¹H- and ¹³C-NMR spectroscopy and ESI-TOF mass spectrometry.
Main Authors
Format
Articles
Journal article
Published
2011
Series
Subjects
Publisher
MDPI
Original source
http://www.mdpi.com/journal/molecules
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201211022843Use this for linking
Review status
Peer reviewed
ISSN
1420-3049
DOI
https://doi.org/10.3390/molecules16086306
Language
English
Published in
Molecules
Citation
- Koivukorpi, J., & Kolehmainen, E. (2011). Synthesis of Both Ionic Species of Ammonium Dithiocarbamate Derived Cholic Acid Moieties. Molecules, 16 (8), 6306-6312. doi:10.3390/molecules16086306 Retrieved from http://www.mdpi.com/journal/molecules/
License
Copyright© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license.