Polymorphism and versatile solvate formation of thiophanate-methyl
Nauha, E., Saxell, H., Nissinen, M., Kolehmainen, E., Schäfer, A., & Schlecker, R. (2009). Polymorphism and versatile solvate formation of thiophanate-methyl. CrystEngComm, 11, 2536-2547. doi:10.1039/B905511H
© The Royal Society of Chemistry. This is an electronic final draft version of the article whose final and definitive form has been published in CrystEngcomm.
The polymorphism of a fungicide, thiophanate-methyl (TM), was investigated with conventional solvent screening methods. Two polymorphs, the thermodynamically most stable form I and the less stable form II, were found. TM was also found to crystallize as a plethora of different solvates which produced mostly form II upon desolvation. The structures of form I and form II and the fourteen discovered solvates were solved by single crystal X-ray diffraction. The most stable forms were further characterized by powder diffraction, thermoanalytical (TG/DTA, DSC and thermomicroscopy) and spectroscopic (IR, Raman, ¹³C CP/MAS NMR) methods.