Showing items with similar title or keywords.

• The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor 

  Eesmaa, Ave; Yu, Li-Ying; Göös, Helka; Nõges, Kristofer; Kovaleva, Vera; Hellman, Maarit; Zimmermann, Richard; Jung, Martin; Permi, Perttu; Varjosalo, Markku; Lindholm, Päivi; Saarma, Mart (Elsevier, 2021)

  Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER-stress regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and ...

• Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax 

  Yang, Dongyan; Zhang, Lei; Zhang, Zhisheng; Hu, Sulei; Fu, Yanbo; Laukkanen, Jari; Li, Gang (Wiley-Blackwell, 2019)

  Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro‐survival and anti‐apoptotic roles through molecule phosphorylated extracellular signal‐regulated kinase1/2 ...

• Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice 

  Puttaraksa, Kanoktip; Pirttinen, Heidi; Karvonen, Kati; Nykky, Jonna; Naides, Stanley J.; Gilbert, Leona (Oxford University Press, 2019)

  Background Viral infection is implicated in development of autoimmunity. Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modifies self double-stranded deoxyribonucleic acid (dsDNA) and induces ...

• Discovery of Potent Indolyl-Hydrazones as Kinase Inhibitors for Breast Cancer : Synthesis, X-ray Single-Crystal Analysis, and In Vitro and In Vivo Anti-Cancer Activity Evaluation 

  Salama, Eid E.; Youssef, Mohamed F.; Aboelmagd, Ahmed; Boraei, Ahmed T. A.; Nafie, Mohamed S.; Haukka, Matti; Barakat, Assem; Sarhan, Ahmed A. M. (MDPI AG, 2023)

  According to data provided by the World Health Organization (WHO), a total of 2.3 million women across the globe received a diagnosis of breast cancer in the year 2020, and among these cases, 685,000 resulted in fatalities. ...

• Cytotoxicity and Apoptosis-Induction in MCF-7 Cells for New Pd(II) Complex Based on s-Triazine Ligand : Synthesis, Single Crystal X-ray Diffraction Analysis and Structural Investigations 

  Alayyaf, Abdulmajeed Abdullah; Barakat, Assem; Al-Majid, Abdullah Mohammed; Ali, M.; Yousuf, Sammer; Haukka, Matti; El-Faham, Ayman; Soliman, Saied M.; Nafie, Mohamed S. (MDPI AG, 2023)

  The synthesis and X-ray structure analysis of the new [PdLCl2]*0.5 CH2Cl2 complex where L is hydrazono-s-triazine di-morpholine derivative, were presented. In the neutral inner sphere of this complex, the organic ligand L ...