Gimap3 & Gimap5 in apoptosis
Related items
Showing items with similar title or keywords.
-
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax
Yang, Dongyan; Zhang, Lei; Zhang, Zhisheng; Hu, Sulei; Fu, Yanbo; Laukkanen, Jari; Li, Gang (Wiley-Blackwell, 2019)Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro‐survival and anti‐apoptotic roles through molecule phosphorylated extracellular signal‐regulated kinase1/2 ... -
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
Eesmaa, Ave; Yu, Li-Ying; Göös, Helka; Nõges, Kristofer; Kovaleva, Vera; Hellman, Maarit; Zimmermann, Richard; Jung, Martin; Permi, Perttu; Varjosalo, Markku; Lindholm, Päivi; Saarma, Mart (Elsevier, 2021)Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER-stress regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and ... -
Pathogenic mechanisms of how human parvovirus breaks self-tolerance
Puttaraksa, Kanoktip (University of Jyväskylä, 2017)It is known that viral infections can cause acute, chronic, and autoimmune diseases (ADs). However, the mechanism of how a persistent viral infection contributes to ADs remains still unclear. In this thesis, pathological ... -
Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice
Puttaraksa, Kanoktip; Pirttinen, Heidi; Karvonen, Kati; Nykky, Jonna; Naides, Stanley J.; Gilbert, Leona (Oxford University Press, 2019)Background Viral infection is implicated in development of autoimmunity. Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modifies self double-stranded deoxyribonucleic acid (dsDNA) and induces ... -
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
Bulanova, Daria; Ianevski, Aleksandr; Bugai, Andrii; Akimov, Yevhen; Kuivanen, Suvi; Paavilainen, Henrik; Kakkola, Laura; Nandania, Jatin; Turunen, Laura; Ohman, Tiina; Ala-Hongisto, Hanna; Pesonen, Hanna M.; Kuisma, Marika S.; Honkimaa, Anni; Walton, Emma L.; Oksenych, Valentyn; Lorey, Martina B.; Guschin, Dmitry; Shim, Jungmin; Kim, Jinhee; Than, Thoa T.; Chang, So Young; Hukkanen, Veijo; Kulesskiy, Evgeny; Marjomäki, Varpu; Julkunen, Ilkka; Nyman, Tuula A.; Matikainen, Sampsa; Saarela, Jani S.; Sane, Famara; Hober, Didier; Gabriel, Gülsah; De Brabander, Jef K.; Martikainen, Miika; Windisch, Marc P.; Min, Ji-Young; Bruzzone, Roberto; Aittokallio, Tero; Vähä-Koskela, Markus; Vapalahti, Olli; Pulk, Arto; Velagapudi, Vidya; Kainov, Denis E. (MDPI, 2017)Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, ...