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Gimap3 & Gimap5 in apoptosis
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The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor Eesmaa, Ave; Yu, Li-Ying; Göös, Helka; Nõges, Kristofer; Kovaleva, Vera; Hellman, Maarit; Zimmermann, Richard; Jung, Martin; Permi, Perttu; Varjosalo, Markku; Lindholm, Päivi; Saarma, Mart (Elsevier, 2021)Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER-stress regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and ...
Silencing of C3G increases cardiomyocyte survival inhibition and apoptosis via regulation of p-ERK1/2 and Bax Yang, Dongyan; Zhang, Lei; Zhang, Zhisheng; Hu, Sulei; Fu, Yanbo; Laukkanen, Jari; Li, Gang (Wiley-Blackwell, 2019)Experimental studies have shown that overexpression of Rap guanine nucleotide exchange factor 1 (C3G) plays pro‐survival and anti‐apoptotic roles through molecule phosphorylated extracellular signal‐regulated kinase1/2 ...
Pathogenic mechanisms of how human parvovirus breaks self-tolerance Puttaraksa, Kanoktip (University of Jyväskylä, 2017)It is known that viral infections can cause acute, chronic, and autoimmune diseases (ADs). However, the mechanism of how a persistent viral infection contributes to ADs remains still unclear. In this thesis, pathological ...