Showing items with similar title or keywords.

• Five-Year Cumulative Exposure to Antipsychotic Medication After First-Episode Psychosis and its Association With 19-Year Outcomes 

  Bergström, Tomi; Taskila, Jyri J.; Alakare, Birgitta; Köngäs-Saviaro, Päivi; Miettunen, Jouko; Seikkula, Jaakko (Oxford University Press (OUP), 2020)

  The long-term effectiveness of antipsychotic maintenance treatment after first-episode psychosis (FEP) is contested. In this real-world observational study, we examined how cumulative exposure to antipsychotics within the ...

• Psykoosilääkehoidon ohjaus voi tehostaa skitsofrenian hoitoa 

  Bergström, Tomi; Hulkko, Anja; Hartikainen, Sirpa; Koponen, Hannu; Lieslehto, Johannes; Jääskeläinen, Erika; Isohanni, Matti (Kustannus Oy Duodecim, 2022)

  Psykoosilääkkeet lievittävät skitsofrenian psykoosioireita ja vähentävät relapsiriskiä. Psykoosilääkityksen pitkäaikaiskäytön hyöty-haittasuhde skitsofrenian hoidossa on osin tuntematon. Etenkin suurten psykoosilääkeannosten ...

• Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors 

  Jokinen, Elmeri M.; Postila, Pekka A.; Ahinko, Mira; Niinivehmas, Sanna; Pentikäinen, Olli T. (Wiley-Blackwell Publishing, Inc., 2019)

  A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific ...

• Psychedelics promote plasticity by directly binding to BDNF receptor TrkB 

  Moliner, Rafael; Girych, Mykhailo; Brunello, Cecilia A.; Kovaleva, Vera; Biojone, Caroline; Enkavi, Giray; Antenucci, Lina; Kot, Erik F.; Goncharuk, Sergey A.; Kaurinkoski, Katja; Kuutti, Mirjami; Fred, Senem M.; Elsilä, Lauri V.; Sakson, Sven; Cannarozzo, Cecilia; Diniz, Cassiano R. A. F.; Seiffert, Nina; Rubiolo, Anna; Haapaniemi, Hele; Meshi, Elsa; Nagaeva, Elina; Öhman, Tiina; Róg, Tomasz; Kankuri, Esko; Vilar, Marçal; Varjosalo, Markku; Korpi, Esa R.; Permi, Perttu; Mineev, Konstantin S.; Saarma, Mart; Vattulainen, Ilpo; Casarotto, Plinio C.; Castrén, Eero (Nature Publishing Group, 2023)

  Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We recently reported that pharmacologically diverse antidepressants, ...

• Long-term use of medication is based on myths and lack of other skills to help people in most severe crises : Commentary to the article of Peter Goetzsche 

  Seikkula, Jaakko (Giovanni Fioriti Editore, 2021)