Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice
Munukka, E., Rintala, A., Toivonen, R., Nylund, M., Yang, B., Takanen, A., Hänninen, A., Vuopio, J., Huovinen, P., Jalkanen, S., & Pekkala, S. (2017). Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. ISME Journal, 11(7), 1667-1679. https://doi.org/10.1038/ismej.2017.24
Julkaistu sarjassa
ISME JournalTekijät
Päivämäärä
2017Tekijänoikeudet
© the Authors, 2017. This is a final draft version of an article whose final and definitive form has been published by Nature Publishing Group. Published in this repository with the kind permission of the publisher.
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice. Compared to the high-fat control mice, F. prausnitzii-treated mice had lower hepatic fat content, aspartate aminotransferase and alanine aminotransferase, and increased fatty acid oxidation and adiponectin signaling in liver. Hepatic lipidomic analyses revealed decreases in several species of triacylglycerols, phospholipids and cholesteryl esters. Adiponectin expression was increased in the visceral adipose tissue, and the subcutaneous and visceral adipose tissues were more insulin sensitive and less inflamed in F. prausnitzii-treated mice. Further, F. prausnitzii treatment increased muscle mass that may be linked to enhanced mitochondrial respiration, modified gut microbiota composition and improved intestinal integrity. Our findings show that F. prausnitzii treatment improves hepatic health, and decreases adipose tissue inflammation in mice and warrant the need for further studies to discover its therapeutic potential.
...
Julkaisija
Nature Publishing GroupISSN Hae Julkaisufoorumista
1751-7362Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/26937899
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [2918]
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Effects of high-fat diet and prebiotic fiber supplementation on hippocampal inflammation and adult neurogenesis
Kunnas, Kari (2021)Paljon energiaa sisältävän ravinnon lisääntyminen osana tavallista ruokavaliota on viimeisten vuosikymmenien aikana todettu johtavan ylipainosta aiheutuviin terveyshaittoihin ja muuttavan suolistomikrobiston rakennetta. ... -
Diagnostics and clinical significance of Faecalibacterium prausnitzii
Rintala, Anniina (2013) -
Vascular Adhesion Protein 1 Mediates Gut Microbial Flagellin-Induced Inflammation, Leukocyte Infiltration, and Hepatic Steatosis
Toivonen, Raine; Vanhatalo, Sanja; Hollmén, Maija; Munukka, Eveliina; Keskitalo, Anniina; Pietilä, Sami; Elo, Laura; Huovinen, Pentti; Jalkanen, Sirpa; Pekkala, Satu (MDPI, 2021)Toll-like receptor 5 ligand, flagellin, and Vascular Adhesion Protein-1 (VAP-1) are involved in non-alcoholic fatty liver disease (NAFLD). This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat ... -
Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats
Lensu, Sanna; Waselius, Tomi; Mäkinen, Elina; Kettunen, Heikki; Virtanen, Ari; Tiirola, Marja; Penttonen, Markku; Pekkala, Satu; Nokia, Miriam S. (Wiley-Blackwell, 2021)Treatment of brain cancer, glioma, can cause cognitive impairment as a side‐effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat ... -
Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering
Hintikka, Jukka; Lensu, Sanna; Mäkinen, Elina; Karvinen, Sira; Honkanen, Marjaana; Lindén, Jere; Garrels, Tim; Pekkala, Satu; Lahti, Leo (MDPI AG, 2021)We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.