Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family

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dc.contributor.author Niskanen, Einari A
dc.contributor.author Hytönen, Vesa P
dc.contributor.author Grapputo, Alessandro
dc.contributor.author Nordlund, Henri R
dc.contributor.author Kulomaa, Markku S
dc.contributor.author Laitinen, Olli H
dc.date.accessioned 2012-11-23T11:20:39Z
dc.date.available 2012-11-23T11:20:39Z
dc.date.issued 2005 fi
dc.identifier.citation Niskanen, E., Hytönen, V., Grapputo, A., Nordlund, H., Kulomaa, M., & Laitinen, O. (2005). Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family. BMC Genomics, (6), 41. doi:10.1186/1471-2164-6-41 fi
dc.identifier.issn 1471-2164
dc.identifier.issn 1471-2164
dc.identifier.uri http://dx.doi.org/10.1186/1471-2164-6-41
dc.identifier.uri http://hdl.handle.net/123456789/40417
dc.description.abstract Background A chicken egg contains several biotin-binding proteins (BBPs), whose complete DNA and amino acid sequences are not known. In order to identify and characterise these genes and proteins we studied chicken cDNAs and genes available in the NCBI database and chicken genome database using the reported N-terminal amino acid sequences of chicken egg-yolk BBPs as search strings. Results Two separate hits showing significant homology for these N-terminal sequences were discovered. For one of these hits, the chromosomal location in the immediate proximity of the avidin gene family was found. Both of these hits encode proteins having high sequence similarity with avidin suggesting that chicken BBPs are paralogous to avidin family. In particular, almost all residues corresponding to biotin binding in avidin are conserved in these putative BBP proteins. One of the found DNA sequences, however, seems to encode a carboxy-terminal extension not present in avidin. Conclusion We describe here the predicted properties of the putative BBP genes and proteins. Our present observations link BBP genes together with avidin gene family and shed more light on the genetic arrangement and variability of this family. In addition, comparative modelling revealed the potential structural elements important for the functional and structural properties of the putative BBP proteins. fi
dc.language.iso eng
dc.publisher BioMed Central (BMC)
dc.relation.ispartofseries BMC Genomics
dc.rights © 2005 Niskanen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other BBP
dc.subject.other avidiini
dc.subject.other biotiini
dc.subject.other avidin
dc.subject.other biotin
dc.title Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family
dc.type Article en
dc.contributor.laitos Bio- ja ympäristötieteiden laitos fi
dc.contributor.laitos The Department of Biological and Environmental Sciences en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1186/1471-2164-6-41
dc.date.updated 2012-11-15T15:00:13Z
dc.description.version Published version
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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