Näytä suppeat kuvailutiedot

dc.contributor.authorNikander, Riku
dc.contributor.authorSievänen, Harri
dc.contributor.authorHeinonen, Ari
dc.contributor.authorDaly, Robin M
dc.contributor.authorUusi-Rasi, Kirsti
dc.contributor.authorKannus, Pekka
dc.date.accessioned2012-11-19T08:41:41Z
dc.date.available2012-11-19T08:41:41Z
dc.date.issued2010
dc.identifier.citationNikander, R., Sievänen, H., Heinonen, A., Daly, R., Uusi-Rasi, K., & Kannus, P. (2010). Targeted Exercise against Osteoporosis: Systematic Review and Meta-Analysis for Optimising Bone Strength throughout Life. BMC Medicine , 8 (47). doi:10.1186/1741-7015-8-47
dc.identifier.urihttp://dx.doi.org/10.1186/1741-7015-8-47
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/40357
dc.description.abstractBackground. Exercise is widely recommended to reduce osteoporosis, falls and related fragility fractures, but its effect on whole bone strength has remained inconclusive. The primary purpose of this systematic review and meta-analysis was to evaluate the effects of long-term supervised exercise (≥6 months) on estimates of lower-extremity bone strength from childhood to older age. Methods. We searched four databases (PubMed, Sport Discus, Physical Education Index, and Embase) up to October 2009 and included 10 randomised controlled trials (RCTs) that assessed the effects of exercise training on whole bone strength. We analysed the results by age groups (childhood, adolescence, and young and older adulthood) and compared the changes to habitually active or sedentary controls. To calculate standardized mean differences (SMD; effect size), we used the follow-up values of bone strength measures adjusted for baseline bone values. An inverse variance-weighted random-effects model was used to pool the results across studies. Results. Our quality analysis revealed that exercise regimens were heterogeneous; some trials were short in duration and small in sample size, and the weekly training doses varied considerably between trials. We found a small and significant exercise effect among pre- and early pubertal boys [SMD, effect size, 0.17 (95% CI, 0.02-0.32)], but not among pubertal girls [-0.01 (-0.18 to 0.17)], adolescent boys [0.10 (-0.75 to 0.95)], adolescent girls [0.21 (-0.53 to 0.97)], premenopausal women [0.00 (-0.43 to 0.44)] or postmenopausal women [0.00 (-0.15 to 0.15)]. Evidence based on per-protocol analyses of individual trials in children and adolescents indicated that programmes incorporating regular weight-bearing exercise can result in 1% to8% improvements in bone strength at the loaded skeletal sites. In premenopausal women with high exercise compliance, improvements ranging from 0.5% to 2.5% have been reported. Conclusions. The findings from our meta-analysis of RCTs indicate that exercise can significantly enhance bone strength at loaded sites in children but not in adults. Since few RCTs were conducted to investigate exercise effects on bone strength, there is still a need for further well-designed, long-term RCTs with adequate sample sizes to quantify the effects of exercise on whole bone strength and its structural determinants throughout life.
dc.language.isoeng
dc.publisherBioMed Central (BMC)
dc.relation.ispartofseriesBMC Medicine
dc.subject.otherosteoporosisen
dc.subject.otherboneen
dc.subject.otherbone strengthen
dc.subject.otherexerciseen
dc.subject.otherosteoporoosifi
dc.subject.otherluustofi
dc.subject.otherluun lujuusfi
dc.subject.otherliikuntafi
dc.titleTargeted exercise against osteoporosis: A systematic review and meta-analysis for optimising bone strength throughout life
dc.typeArticle
dc.identifier.urnURN:NBN:fi:jyu-201804202276
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2012-11-15T14:51:27Z
dc.rights.holderRiku Nikander et al.; licensee BioMed Central Ltd.
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn1741-7015
dc.type.versionpublishedVersion
dc.rights.copyright© 2010 Nikander et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/2.0
dc.relation.doi10.1186/1741-7015-8-47


Aineistoon kuuluvat tiedostot

Thumbnail
Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

Riku Nikander et al.; licensee BioMed Central Ltd.
Ellei muuten mainita, aineiston lisenssi on Riku Nikander et al.; licensee BioMed Central Ltd.