Interactive effects between diet and genotypes of host and pathogen define the severity of infection

DSpace/Manakin Repository

Show simple item record

dc.contributor.author Zhang, Ji
dc.contributor.author Friman, Ville-Petri
dc.contributor.author Laakso, Jouni
dc.contributor.author Mappes, Johanna
dc.date.accessioned 2012-10-31T08:30:04Z
dc.date.available 2012-10-31T08:30:04Z
dc.date.issued 2012
dc.identifier.citation Zhang, J., Friman, V.-P., Laakso, J., & Mappes, J. (2012). Interactive effects between diet and genotypes of host and pathogen define the severity of infection. Ecology and Evolution, 2 (9), 2347 2356. doi:10.1002/ece3.356 Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/ece3.356/full fi
dc.identifier.issn 2045-7758
dc.identifier.other TUTKAID_51954
dc.identifier.uri http://hdl.handle.net/123456789/40135
dc.description.abstract Host resistance and parasite virulence are influenced by multiple interacting factors in complex natural communities. Yet, these interactive effects are seldom studied concurrently, resulting in poor understanding of host-pathogen-environment dynamics. Here, we investigated how the level of opportunist pathogen virulence, strength of host immunity and the host condition manipulated via diet affect the survival of wood tiger moth Parasemia plantaginis (Arctidae). Larvae from “low cuticular melanin” and “high cuticular melanin” (considered as low and high pathogen resistance, respectively) selection lines were infected with moderately and highly virulent bacteria strains of Serratia marcescens, while simultaneously manipulating host diet (with or without antibacterial compounds). We measured host survival and food preference before and after infection to test whether the larvae “self-medicate” by choosing an anti-infection diet (Plantago major, i.e., plantain leaf) over lettuce (Lactuca sativa). “High melanin” larvae were more resistant than “low melanin” larvae to the less virulent strain that had slower growth and colonization rate compared with the more virulent strain. Cuticular melanin did not enhance survival when the larvae were infected with the highly virulent strain. Anti-infection diet enhanced survival of the “high melanin” but not the “low melanin” hosts. Survival was dependent on family origin even within the melanin selection lines. Despite the intrinsic preference for lettuce, no evidence of self-medication was found. These results demonstrate that the relative benefit of host cuticular melanin depends on both diet and pathogen virulence: plantain diet only boosted the immunity of already resistant “high melanin” hosts, and cuticular melanin increased host survival only when infected with moderately virulent pathogen. Moreover, there was considerable variation in host survival between families within both melanin lines suggesting genetic basis for resistance. These results indicate that although melanin is an important predictor of insect immunity, its effect on disease outcomes greatly depends on other interacting factors.
dc.language.iso eng
dc.publisher Blackwell Publishing Ltd.
dc.relation.ispartof Ecology and Evolution
dc.relation.uri http://onlinelibrary.wiley.com/doi/10.1002/ece3.356/full
dc.subject.other Genotyyppi-ympäristö vuorovaikutus fi
dc.subject.other immunokompetenssille fi
dc.subject.other Parasemia plantaginis fi
dc.subject.other Plantago major fi
dc.subject.other Serratia marcescens fi
dc.subject.other virulenssi fi
dc.subject.other Genotype-environment interaction fi
dc.subject.other immunocompetence fi
dc.subject.other Parasemia plantaginis fi
dc.subject.other Plantago major fi
dc.subject.other Serratia marcescens fi
dc.subject.other virulence fi
dc.title Interactive effects between diet and genotypes of host and pathogen define the severity of infection
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-201210302813
dc.subject.kota 1181
dc.contributor.laitos Bio- ja ympäristötieteiden laitos
dc.contributor.laitos The Department of Biological and Environmental Sciences en
dc.contributor.oppiaine ekologia ja evoluutiobiologia fi
jyx.tutka.volyme 2
jyx.tutka.mnumber 9
jyx.tutka.pagetopage 2347 2356
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi 10.1002/ece3.356
dc.date.updated 2012-10-30T04:30:04Z
eprint.status http://purl.org/eprint/type/status/PeerReviewed

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record