Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study

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dc.contributor.author Karjalainen, Jouko
dc.contributor.author Tikkanen, Heikki
dc.contributor.author Hernelahti, Miika
dc.contributor.author Kujala, Urho
dc.date.accessioned 2011-05-13T07:31:28Z
dc.date.available 2011-05-13T07:31:28Z
dc.date.issued 2006
dc.identifier.citation Karjalainen, J., Tikkanen, H., Hernelahti, M. & Kujala, U. (2006). Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study. BMC Cardiovascular Disorders, 6 (2). Retrieved from http://www.biomedcentral.com/1471-2261/6/2
dc.identifier.issn 1471-2261
dc.identifier.uri http://hdl.handle.net/123456789/26958
dc.description.abstract BACKGROUND: Skeletal muscle consists of type-I (slow-twitch) and type-II (fast-twitch) fibers, with proportions highly variable between individuals and mostly determined by genetic factors. Cross-sectional studies have associated low percentage of type-I fibers (type-I%) with many cardiovascular risk factors. METHODS: We investigated whether baseline type-I% predicts left ventricular (LV) structure and function at 19-year follow-up, and if so, which are the strongest mediating factors. At baseline in 1984 muscle fiber-type distribution (by actomyosin ATPase staining) was studied in 63 healthy men (aged 32–58 years). The follow-up in 2003 included echocardiography, measurement of obesity related variables, physical activity and blood pressure. RESULTS: In the 40 men not using cardiovascular drugs at follow-up, low type-I% predicted higher heart rate, blood pressure, and LV fractional shortening suggesting increased sympathetic tone. Low type-I% predicted smaller LV chamber diameters (P ≤ 0.009) and greater relative wall thickness (P = 0.034) without increase in LV mass (concentric remodeling). This was explained by the association of type-I% with obesity related variables. Type-I% was an independent predictor of follow-up body fat percentage, waist/hip ratio, weight gain in adulthood, and physical activity (in all P ≤ 0.001). After including these risk factors in the regression models, weight gain was the strongest predictor of LV geometry explaining 64% of the variation in LV end-diastolic diameter, 72% in end-systolic diameter, and 53% in relative wall thickness. CONCLUSION: Low type-I% predicts obesity and weight gain especially in the mid-abdomen, and consequently unfavourable LV geometry indicating increased cardiovascular risk. en
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Cardiovascular Disorders
dc.rights © 2006 Karjalainen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2
dc.subject.other lihassolu en
dc.subject.other lihavuus en
dc.subject.other sydän en
dc.subject.other liikunta en
dc.subject.other muscle fiber-type en
dc.subject.other obesity en
dc.subject.other heart en
dc.subject.other physical activity en
dc.title Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-2011051310797
dc.subject.kota
dc.contributor.laitos Terveystieteiden laitos fi
dc.contributor.laitos Department of Health Sciences en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1186/1471-2261-6-2
dc.description.version Published PDF
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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