Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study

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Show simple item record Karjalainen, Jouko Tikkanen, Heikki Hernelahti, Miika Kujala, Urho 2011-05-13T07:31:28Z 2011-05-13T07:31:28Z 2006
dc.identifier.citation Karjalainen, J., Tikkanen, H., Hernelahti, M. & Kujala, U. (2006). Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study. BMC Cardiovascular Disorders, 6 (2). Retrieved from
dc.identifier.issn 1471-2261
dc.description.abstract BACKGROUND: Skeletal muscle consists of type-I (slow-twitch) and type-II (fast-twitch) fibers, with proportions highly variable between individuals and mostly determined by genetic factors. Cross-sectional studies have associated low percentage of type-I fibers (type-I%) with many cardiovascular risk factors. METHODS: We investigated whether baseline type-I% predicts left ventricular (LV) structure and function at 19-year follow-up, and if so, which are the strongest mediating factors. At baseline in 1984 muscle fiber-type distribution (by actomyosin ATPase staining) was studied in 63 healthy men (aged 32–58 years). The follow-up in 2003 included echocardiography, measurement of obesity related variables, physical activity and blood pressure. RESULTS: In the 40 men not using cardiovascular drugs at follow-up, low type-I% predicted higher heart rate, blood pressure, and LV fractional shortening suggesting increased sympathetic tone. Low type-I% predicted smaller LV chamber diameters (P ≤ 0.009) and greater relative wall thickness (P = 0.034) without increase in LV mass (concentric remodeling). This was explained by the association of type-I% with obesity related variables. Type-I% was an independent predictor of follow-up body fat percentage, waist/hip ratio, weight gain in adulthood, and physical activity (in all P ≤ 0.001). After including these risk factors in the regression models, weight gain was the strongest predictor of LV geometry explaining 64% of the variation in LV end-diastolic diameter, 72% in end-systolic diameter, and 53% in relative wall thickness. CONCLUSION: Low type-I% predicts obesity and weight gain especially in the mid-abdomen, and consequently unfavourable LV geometry indicating increased cardiovascular risk. en
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Cardiovascular Disorders
dc.rights openAccess fi
dc.rights © 2006 Karjalainen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subject.other lihassolu en
dc.subject.other lihavuus en
dc.subject.other sydän en
dc.subject.other liikunta en
dc.subject.other muscle fiber-type en
dc.subject.other obesity en
dc.subject.other heart en
dc.subject.other physical activity en
dc.title Muscle fiber-type distribution predicts weight gain and unfavourable left ventricular geometry: a 19 year follow-up study
dc.type Article
dc.identifier.urn URN:NBN:fi:jyu-2011051310797
dc.contributor.laitos Terveystieteiden laitos fi
dc.contributor.laitos Department of Health Sciences en
dc.identifier.doi doi:10.1186/1471-2261-6-2
dc.description.version Publisher's PDF
dc.type.coar journal article
dc.description.reviewStatus peerReviewed
dc.relation.issn 1471-2261
dc.type.version publishedVersion
dc.rights.accessLevel openAccess

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