High Temperature and Bacteriophages Can Indirectly Select for Bacterial Pathogenicity in Environmental Reservoirs

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dc.contributor.author Friman, Ville-Petri
dc.contributor.author Hiltunen, Teppo
dc.contributor.author Jalasvuori, Matti
dc.contributor.author Lindstedt, Carita
dc.contributor.author Laanto, Elina
dc.contributor.author Örmälä, Anni-Maria
dc.contributor.author Laakso, Jouni
dc.contributor.author Mappes, Johanna
dc.date.accessioned 2011-05-13T06:15:23Z
dc.date.available 2011-05-13T06:15:23Z
dc.date.issued 2011
dc.identifier.citation Friman V-P, Hiltunen T, Jalasvuori M, Lindstedt C, Laanto E, et al. 2011 High Temperature and Bacteriophages Can Indirectly Select for Bacterial Pathogenicity in Environmental Reservoirs. PLoS ONE 6(3): e17651. doi:10.1371/journal.pone.0017651
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/123456789/26954
dc.description.abstract The coincidental evolution hypothesis predicts that traits connected to bacterial pathogenicity could be indirectly selected outside the host as a correlated response to abiotic environmental conditions or different biotic species interactions. To investigate this, an opportunistic bacterial pathogen, Serratia marcescens, was cultured in the absence and presence of the lytic bacteriophage PPV (Podoviridae) at 25uC and 37uC for four weeks (N = 5). At the end, we measured changes in bacterial phage-resistance and potential virulence traits, and determined the pathogenicity of all bacterial selection lines in the Parasemia plantaginis insect model in vivo. Selection at 37uC increased bacterial motility and pathogenicity but only in the absence of phages. Exposure to phages increased the phage-resistance of bacteria, and this was costly in terms of decreased maximum population size in the absence of phages. However, this small-magnitude growth cost was not greater with bacteria that had evolved in high temperature regime, and no trade-off was found between phage-resistance and growth rate. As a result, phages constrained the evolution of a temperature-mediated increase in bacterial pathogenicity presumably by preferably infecting the highly motile and virulent bacteria. In more general perspective, our results suggest that the traits connected to bacterial pathogenicity could be indirectly selected as a correlated response by abiotic and biotic factors in environmental reservoirs. en
dc.language.iso eng
dc.relation.ispartofseries PLoS ONE
dc.rights © 2011 Friman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.title High Temperature and Bacteriophages Can Indirectly Select for Bacterial Pathogenicity in Environmental Reservoirs
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-2011051310794
dc.subject.kota 118
dc.contributor.laitos Bio- ja ympäristötieteiden laitos fi
dc.contributor.laitos Department of Biological and Environmental Science en
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1371/journal.pone.0017651
dc.description.version Published version
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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