Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes

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dc.contributor.author Mero, Antti A.
dc.contributor.author Ojala, Tuomo AM
dc.contributor.author Hulmi, Juha J.
dc.contributor.author Puurtinen, Risto
dc.contributor.author Seppälä, Timo
dc.date.accessioned 2011-05-11T07:59:24Z
dc.date.available 2011-05-11T07:59:24Z
dc.date.issued 2010
dc.identifier.citation Mero, A., Ojala, T., Hulmi, J., Puurtinen, R., Karila, T. & Seppälä, T. (2010). Effects of alfa-hydroxy-isocaproic acid on body composition, doms and performance in athletes. Journal of the International Society of Sports Nutrition, 7 (1), 1-8. doi:10.1186/1550-2783-7-1
dc.identifier.issn 1550-2783
dc.identifier.uri http://hdl.handle.net/123456789/26936
dc.description.abstract Background. Alfa-Hydroxy-isocaproic acid (HICA) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. According to the clinical and experimental studies, HICA can be considered as an anti-catabolic substance. The present study investigated the effects of HICA supplementation on body composition, delayed onset of muscle soreness (DOMS) and physical performance of athletes during a training period. Methods. Fifteen healthy male soccer players (age 22.1+/-3.9 yr) volunteered for the 4-week double-blind study during an intensive training period. The subjects in the group HICA (n = 8) received 583 mg of sodium salt of HICA (corresponding 500 mg of HICA) mixed with liquid three times a day for 4 weeks, and those in the group PLACEBO (n = 7) received 650 mg of maltodextrin mixed with liquid three times a day for the same period. According to a weekly training schedule, they practiced soccer 3 - 4 times a week, had strength training 1 - 2 times a week, and had one soccer game during the study. The subjects were required to keep diaries on training, nutrition, and symptoms of DOMS. Body composition was evaluated with a dual-energy X-ray absorptiometry (DXA) before and after the 4-week period. Muscle strength and running velocity were measured with field tests. Results. As compared to placebo, the HICA supplementation increased significantly body weight (p < 0.005) and whole lean body mass (p < 0.05) while fat mass remained constant. The lean body mass of lower extremities increased by 400 g in HICA but decreased by 150 g in PLACEBO during the study. This difference between the groups was significant (p < 0.01). The HICA supplementation decreased the whole body DOMS symptoms in the 4th week of the treatment (p < 0.05) when compared to placebo. Muscle strength and running velocity did not differ between the groups. Conclusion. Already a 4-week HICA supplementation of 1.5 g a day leads to small increases in muscle mass during an intensive training period in soccer athletes. en
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries Journal of the International Society of Sports Nutrition
dc.rights © 2010 Mero et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/2.0
dc.subject.other alfa HICA en
dc.subject.other kehonkoostumus en
dc.subject.other suorituskyky en
dc.title Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes
dc.type Article en
dc.identifier.urn URN:NBN:fi:jyu-2011051110776
dc.subject.kota
dc.contributor.laitos Liikuntabiologian laitos fi
dc.contributor.laitos Department of Biology of Physical Activity en
dc.contributor.oppiaine
dc.type.uri http://purl.org/eprint/type/JournalArticle
dc.identifier.doi doi:10.1186/1550-2783-7-1
dc.description.version Published PDF
eprint.status http://purl.org/eprint/type/status/PeerReviewed

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