Protein levels of brain-derived neurotrophic factor in the hippocampus of low/high aerobic capacity rats

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dc.contributor.author Mertikas, Georgios
dc.date.accessioned 2010-11-26T12:23:57Z
dc.date.available 2010-11-26T12:23:57Z
dc.date.issued 2010
dc.identifier.uri http://urn.fi/URN:NBN:fi:jyu-201011263121 en
dc.identifier.uri http://hdl.handle.net/123456789/25639
dc.description.abstract Hippocrates and Plato have first documented the connection between a healthy mind and body, during a period which launched analytical thinking and philosophy in Ancient Greece. Modern research has also indicated the contribution of an active lifestyle to enhanced brain performance and decreased incidence of neurodegenerative diseases and mood disorders such as Alzheimer’s disease and depression respectively. This has been hypothesized to emerge through mechanisms which are enhanced by exercise and contribute on brain plas-ticity and health. The Neurotrophins hypothesis implicates several molecules in brain plasticity and healthy aging. Among them, Brain-derived Neurotrophic Factor (BDNF) has been shown to in-crease its expression levels in the most plastic regions of the brain in an activity-dependent manner both in development and adulthood, proposing its significance throughout lifespan. We used Immunohistochemistry (IHC) to investigate the expression of BDNF protein le-vels in the hippocampi of Low/High aerobic capacity rats which have proposed a model of sedentary and active lifestyle. Rats were also subjected to Rotarod motor learning test were the high capacity group showed increased baseline performance and faster learning than the low capacity one. IHC in the hippocampi of the animals didn’t detect any significant differ-ences of BDNF protein levels in CA1 and CA3 areas. The failure to detect differences is believed to emerge due to the sedentary lifestyle in both groups, suggesting that genetic background may not determine the levels of the protein in sedentary conditions.
dc.format.extent 75
dc.language.iso eng
dc.rights This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. en
dc.rights Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. fi
dc.subject.other Brain-derived Neurotrophic Factor
dc.subject.other BDNF
dc.subject.other hippocampus
dc.subject.other synaptic plasticity
dc.subject.other muscle activation
dc.subject.other synaptic plasticity
dc.subject.other neurodegenerative disorders
dc.subject.other muscle activation
dc.subject.other aerobic capacity
dc.subject.other metabolic syndrome
dc.subject.other neurodegenerative disorders
dc.subject.other depression
dc.title Protein levels of brain-derived neurotrophic factor in the hippocampus of low/high aerobic capacity rats
dc.type Book en
dc.identifier.urn URN:NBN:fi:jyu-201011263121
dc.subject.ysa hippokampus
dc.subject.ysa aivot
dc.subject.ysa liikunta
dc.type.dcmitype Text en
dc.type.ontasot Pro gradu fi
dc.type.ontasot Master’s thesis en
dc.contributor.tiedekunta Liikuntatieteellinen tiedekunta fi
dc.contributor.tiedekunta Faculty of Sport and Health Sciences en
dc.contributor.laitos Liikuntabiologian laitos fi
dc.contributor.laitos Department of Biology of Physical Activity en
dc.contributor.yliopisto University of Jyväskylä en
dc.contributor.yliopisto Jyväskylän yliopisto fi
dc.contributor.oppiaine Exercise Physiology en

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