Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction
Abstract
A new organocatalytic enantioselective Strecker reaction of
pyrazolone-derived ketimine electrophiles has been developed.
Using pseudo-enantiomeric squaramide catalysts the nucleophilic
1,2-addition of trimethylsilyl cyanide to the ketimines efficiently
provides a direct entry to both enantiomers of pyrazolone α-
aminonitrile derivatives at will in good yields and high
enantioselectivities for a wide variety of substrates.
Main Authors
Format
Articles
Research article
Published
2017
Series
Subjects
Publication in research information system
Publisher
Royal Society of Chemistry
The permanent address of the publication
https://urn.fi/URN:NBN:fi:jyu-201706283130Use this for linking
Review status
Peer reviewed
ISSN
1359-7345
DOI
https://doi.org/10.1039/C7CC02874A
Language
English
Published in
Chemical Communications
Citation
- Mahajan, S., Chauhan, P., Kaya, U., Deckers, K., Rissanen, K., & Enders, D. (2017). Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction. Chemical Communications, 53(49), 6633-6636. https://doi.org/10.1039/C7CC02874A
Copyright© The Royal Society of Chemistry 2017. This is a final draft version of an article whose final and definitive form has been published by RSC. Published in this repository with the kind permission of the publisher.